421-83-0Relevant articles and documents
Preparation method of N-phenyl-bis(trifluoromethanesulfonyl)imide
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Paragraph 0026-0027; 0029-0030; 0032-0033; 0035, (2021/05/26)
The invention provides a preparation method of N-phenyl-bis(trifluoromethanesulfonyl)imide. The preparation method comprises the following steps: subjecting trifluoromethanesulfonic acid to reacting with thionyl chloride to produce trifluoromethanesulfonyl chloride; and dissolving aniline in a solvent, adding organic alkali such as triethylamine as an acid-binding agent, and dropwise adding trifluoromethanesulfonyl chloride to prepare N-phenyl-bis(trifluoromethanesulfonyl)imide. According to the invention, raw materials are cheap and easily available; trifluoromethanesulfonyl chloride participates in reaction, the utilization rate of groups is high, and the reaction is efficient; special devices such as low-temperature or under-pressure devices are not needed, and operation is easy; and basically no solid three wastes are generated.
Naphthalimide and quinoline derivatives as inhibitors for insect N-acetyl-β-D-hexosaminidase
Yang, Huibin,Qi, Huitang,Liu, Tian,Shao, Xusheng,Yang, Qing,Qian, Xuhong
supporting information, p. 977 - 980 (2019/02/13)
Insect chitinolytic β-N-acetyl-D-hexosaminidase, such as OfHex1 from Ostrinia furnacalis, is a potential target for insecticide design. Among the known OfHex1 inhibitors, Q2 is of great interest because it is the first non-carbohydrate inhibitor. In this study, we designed and synthesized a series of Q2 derivatives by replacing the thiadiazole and naphthalimide groups and changing the linker length. Compound 3m showed the best inhibitory activity with a Ki value of 0.34 μmol/L against OfHex1, which is about one-quarter that of Q2 (Ki = 1.4 μmol/L). Compound 6a showed the best inhibitory activity among the quinoline-containing derivatives (Ki = 2.3 μmol/L). Molecular docking indicated that although 3m, 6a, and Q2 binding the active pocket of OfHex1 in similar mode, compound 3m engaged better than the other compounds in intermolecular interaction with OfHex1.
Transition-Metal-Free Electrophilic Fluoroalkanesulfinylation of Electron-Rich (Het)Arenes with Fluoroalkyl Heteroaryl Sulfones via C(Het)?S and S=O Bond Cleavage
Wei, Jun,Bao, Kun,Qi, Chengcheng,Liu, Yao,Ni, Chuanfa,Sheng, Rong,Hu, Jinbo
supporting information, p. 5528 - 5533 (2019/11/14)
A novel Ph2P(O)Cl-mediated direct fluoroalkanesulfinylation of electron-rich (het)arenes using fluoroalkyl heteroaryl sulfones as the RfSO source (Rf=C4F9, CF2Cl, CF2Br, and CF2COOEt) was developed. This is the first example where 2-HetSO2Rf performs as the RfSO synthon in organic synthesis via both C(Het)?S and S=O bond cleavage. (Figure presented.).
Synthesis method of trimethoxystilbene
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Paragraph 0014, (2016/10/09)
The invention discloses a synthesis method of trimethoxystilbene. The method comprises the following steps of (1) at room temperature, adding trifluoromethanesulfonic acid into dichloromethane; stirring the mixture; slowly dripping sulfoxide chloride; after the dripping is completed, performing stirring reaction for 12 hours at room temperature; concentrating a reaction system to obtain a coarse product of trifluoromethanesulfonyl chloride; (2) adding aniline and triethylamine into dichloromethane; lowering the temperature to 0 DEG C; dripping the obtained coarse product of trifluoromethanesulfonyl chloride through a dropping funnel; after the dripping is completed, raising the temperature to room temperature for reaction for 2 hours; performing water washing, drying and concentration on the reaction system; then, performing recrystallization by petroleum ether to obtain trimethoxystilbene. The synthesis method has the beneficial effects that the raw materials of trifluoromethanesulfonic acid used by the synthesis method of trimethoxystilbene provided by the invention are common chemical raw materials; the price is low; the acquisition is easy; the cost is greatly reduced; special equipment such as low-temperature kettles is not needed in the production process; the operation is easy; the method is suitable for industrial production.
METHOD FOR PREPARING A SULFONIMIDE COMPOUND AND SALTS THEREOF
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Paragraph 0360-0364, (2015/07/27)
The present invention relates to a method for preparing an aqueous sulfonimide compound of the formula (Rf1—SO2) (Rf2—SO2)NH, wherein Rf1et Rf2 are independently selected from the group comprising: a fluorine atom and groups having 1 to 10 carbon atoms selected from the perfluoroalkyl, fluoroalkyl, fluoroalkenyl and fluoroallyl groups, from a mixture M1 including (Rf1—SO2)(Rf2—SO2)NH, Rf1SO2H and/or Rf2SO2H, Rf1SO2NH2 and/or Rf2SO2NH2, characterized in that said method includes an oxidation step of said mixture M1 using an oxidizing agent in order to obtain a mixture M2 including (Rf1—SO2)(Rf2—SO2)NH, Rf1SO3H and/or Rf2SO3H, and Rf1SO2NH2 and/or Rf2SO2NH2.
The method for manufacturing the same and sulfoneimido compd. (by machine translation)
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Paragraph 0307; 0308; 0309, (2017/01/02)
The present invention relates to a method for preparing an aqueous sulfonimide compound of the formula (Rf1—SO2) (Rf2—SO2)NH, wherein Rf1et Rf2 are independently selected from the group comprising: a fluorine atom and groups having 1 to 10 carbon atoms selected from the perfluoroalkyl, fluoroalkyl, fluoroalkenyl and fluoroallyl groups, from a mixture M1 including (Rf1—SO2)(Rf2—SO2)NH, Rf1SO2H and/or Rf2SO2H, Rf1SO2NH2 and/or Rf2SO2NH2, characterized in that said method includes an oxidation step of said mixture M1 using an oxidizing agent in order to obtain a mixture M2 including (Rf1—SO2)(Rf2—SO2)NH, Rf1SO3H and/or Rf2SO3H, and Rf1SO2NH2 and/or Rf2SO2NH2.
(METH)ACRYLATE COMPOUND, OPTICAL COMPOSITION, MOLDED ARTICLE, AND OPTICAL ELEMENT
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Page/Page column, (2015/07/02)
An optical element including a molded article is provided, the molded article being prepared by molding a polymer prepared by polymerizing a (meth)acrylate compound represented at least by the following general formula (1): wherein a and b are each an integer of 1 or 2; X and Y are each —S— or —O—; R1 and R2 are each an alkyl group having 1 or 2 carbon atoms or a hydrogen atom; and Z1 and Z2 are each an alkyl group having 1 or 2 carbon atoms, having a substituent and represented by the following general formula (2): wherein m is selected from 0 and 1; W is a hydrogen atom or a methyl group; and V is selected from substituents represented by the following: *—O—CnH2n—O—**; *—S—CnH2n—S—**; and *—S—CnH2n—O—**, wherein * represents a bond with an alkyl group; ** represents a bond with a (meth)acryloyl group; n is selected from 2, 3 and 4; and at least one hydrogen atom of —CnH2n— is replaced by a methyl group.
A PROCESS FOR THE MANUFACTURE OF TRIFLIC ACID
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Page/Page column 11-12, (2011/09/30)
The present invention relates to a process for the preparation of triflic acid by chloroxidation.
DERIVATIVES OF ETHYLENE METHANEDISULFONATE AS CANCER CHEMOTHERAPEUTIC AGENTS
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, (2009/07/18)
The present application discloses derivatives of ethylene methanedisulfonate as cancer chemotherapeutic agents and methods of synthesizing such derivatives. The derivatives include modifications of ethylene methanedisulfonate by replacing one or both of the chemically most reactive hydrogens of the cyclic sulfonate ester structure. The derivatives of ethylene methanedisulfonate are more active than the parent ester (i.e., ethylene methanedisulfonate) as anticancer agents against a variety of cancers.
Synthesis of trifluoromethanesulfonic acid from CHF3
Mukhopadhyay, Sudip,Bell, Alexis T.,Vijay Srinivas,Smith, Gary S.
, p. 660 - 662 (2013/09/02)
Trifluoromethane is transformed to trifluoromethanesulfonic acid (TFMSA) at low temperature in a liquid-phase reaction in a strong acid such as fuming sulfuric acid as well as in a strong basic solution such as t-BuOK/DMF.
